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Diabetes and obesity are chronic disorders that are on the rise worldwide. BMI is directly proportional to diabetes and insulin resistance. An increase is noticed in substances like the amount of NEFA, glycerol, hormones and cytokines that are involved in the development of insulin resistance in an obese individual. The development of diabetes is incurred by the impairment of β-cell function to the Insulin resistance. Type 1 diabetes is associated with obesity. It is majorly seen in people who are obese from there early life. NEFA is a cornerstone in the development of insulin resistance and in the impairment of β-cell function. Based on these facts new approaches in managing and preventing diabetes in obese individuals must be studied.

Diabetes drug research market in Europe is expected to progress with a 5.08% CAGR over the forecast years of 2018-2026. It is the second largest market for diabetes drugs. High blood glucose kills about 3.4 million people annually worldwide. Approximately 80% of these deaths take place in underdeveloped and developing countries, and almost half are people aged less than 70 years. As per recent research in WHO diabetic deaths will double between 2005 and 2030. India had 69.2 million people living with diabetes (8.7%) in 2015. About 90% of the patients are suffering from Type 2 diabetes. Diabetes Research Market is expected to grow at the average CAGR of 6.5% time period of 2016-2023. India’s Diabetes Market is growing rapidly. India is expected to grow US$ 7441.6 million by 2023 from US$ 4778.7 million in 2016. The data varies from $263 billion spent in North America to $147 billion in Europe and Northern Asia followed by China, Mongolia, South East Asia and Oceania with a total of $88 billion.



In accordance with the market research report by TMR, the world diabetes drugs market stood at a market valuation of around US$ 43.1 bn in the year 2016 and the said market is likely to be valued at around US$ 58.4 bn by the end of the year 2025, rising at a growth rate of 3.6% CAGR over the period of forecast that extends from the year 2017 to 2025. Most of the market revenue was accounted in the region of North America, owing to high prevalence of diabetes in the said region in 2016. The second largest share of the market was acquired by the region of Europe in the year 2016 due to the hike in venture in R & D activities and a very promising export of various diabetes drugs in the said region. Asia Pacific is also expanding fast, leading to the better awareness promotion.



Body mass index features a robust relationship to polygenic disease  and hypoglycemic agent resistance. In corpulent people, the quantity of nonesterified fatty acids, glycerol, hormones, cytokines, unhealthy markers, and alternative substances that area unit concerned within the development of hypoglycemic agent resistance, is multiplied. The pathological process within the development of polygenic disease is predicated on the very fact that the β-islet cells of the duct gland area unit impaired, inflicting an absence of management of glucose. The event of polygenic disease becomes additional inevitable if the failure of β-islet cells of the duct gland is amid hypoglycemic agent resistance. Weight gain and body mass area unit central to the formation and rising incidence of kind one and kind a pair of polygenic disease. This literature review can demonstrate the facts that link avoirdupois with hypoglycemic agent resistance and duct gland β-cell dysfunction. Lastly, new approaches in managing and preventing polygenic disease in corpulent people should be studied and investigated supported the facts. A report in the week in Science proposes that being overweight stresses the insides of individual cells. Specifically, mortal sin stresses the membranous network inside cells known as endoplasmic reticulum. Once the ER has additional nutrients to method than it will handle, it sends out AN alarm signal telling the cell to dampen down the hypoglycemic agent receptors on the cell surface. This interprets to hypoglycemic agent resistance and to persistently high concentrations of the sugar aldohexose within the blood is one among the positive signs of polygenic disease.



The 3rd World Congress on Diabetes and Obesity happening during March 18-20, 2019 in Rome, Italy is themed around “Recent advances in Diabetes and Obesity” with the aim to assemble a large audience of trade, healthcare, research, and medical practitioners to coach and produce a few fruitful discussions on the confined topics. This can be an excellent event to network, learn and have interaction with professionals within the field of polygenic disease and fat.



The DIABETES CONFERENCE 2019  lays a platform for the Diabetologist, endocrinologists and experts both from Industry and Academia working in various subdomains of diabetes, endocrinology and metabolism. The Diabetes and Obesity conference is open for all the Diabetes Doctors, Specialists, Endocrinologists, Researchers, Physicians, Business Analysts, Academicians, Lab Technicians, Nurses, Diabetes Educators, Nutritionists and Dietitians.